Kindly provide clinical studies on the benefits of collagen for bone & skin health


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  1. Ricebowl Food Expert
    October 14, 2019 at 11:48 am

    Collagen is the most abundant protein in human body where there is about 30 % of our total body protein is collagen. The efficacies of collagen in supporting skin and bone health are supported by an extensive body of scientific studies.



    Clinical Studies: Collagen For Beauty/Skin Health


    No. References Findings
    1. Proksch et al., 2014a
    • The objective of this research was to study the effectiveness of collagen hydrolysate (CH) composed of specific collagen peptides on skin biophysical parameters related to cutaneous aging.
    • 69 women aged 35-55 years were randomized to receive 2.5 g or 5.0 g of CH or placebo once daily for 8 weeks, with 23 subjects being allocated to each treatment group.
    • Skin elasticity, skin moisture, transepidermal water loss and skin roughness were objectively measured before the first oral product application and after 4 and 8 weeks of regular intake. Skin elasticity (primary interest) was also assessed at follow-up 4 weeks after the last intake of CH.
    • At the end of the study, skin elasticity in both CH dosage groups showed a statistically significant improvement in comparison to placebo.
    • After 4 weeks of follow-up treatment, a statistically significantly higher skin elasticity level was determined in elderly women.
    2. Asserin et al., 2015
    • Two placebo-controlled clinical trials to assess the effect of daily oral supplementation with collagen peptides on skin hydration and collagen density in volunteers.
    • After 4 weeks of supplementation, dermal collagen deposition significantly increased and, by 8 weeks, skin hydration significantly increased.
    • Both enhanced skin parameters persisted after 12 weeks and the ex vivo results showed that collagen peptides induced collagen as well as glycosaminoglycan production
    3. Hakuta et al., 2017
    • A clinical study of 17 patients with atopic dermatitis are randomly assigned to receive a daily (for 12 weeks) 3.9 g of either collagen tripeptide or normal collagen peptides and each subject served as their own control.
    • When their keratinocytes were analysed, several inflammatory biomarkers were reduced and, in the 13 subjects that completed the study, trans-epidermal water loss was significantly reduced, but the blood parameters were not improved in either treatment group
    4. Proksch et al., 2014b
    • This study examined the influence of a specific bioactive collagen peptide VERISOL in 114 women aged 45-65 years of age that were randomized to receive 2.5 g VERISOL or placebo once daily for eight weeks.
    • By suction blister biopsies, a variety of skin parameters were analysed.
    • With the ingestion of VERISOL, at 4 and 8 weeks, a significant reduction in eye wrinkle volume occurred and, at eight weeks, significantly higher procollagen type I and elastin levels were quantified, which suggests that oral administration of collagen peptides (via VERISOL) reduced skin wrinkles and skin aging
    5. Kim et al., 2018
    • The aim of this study was to conduct a clinically evaluate the effect on human skin hydration, wrinkling, and elasticity of Low-molecular-weight Collagen peptide (LMWCP) with a tripeptide.
    • 64 individualswere randomly assigned to receive either placebo or 1000 mg of LMWCP once daily for 12 weeks.
    • Parameters of skin hydration, wrinkling, and elasticity were assessed at baseline and after 6 weeks and 12 weeks.
    • Compared with the placebo group, skin-hydration values were significantly higher in the LMWCP group after 6 weeks and 12 weeks.
    • After 12 weeks in the LMWCP group, visual assessment score and three parameters of skin wrinkling were significantly improved.
    • In case of skin elasticity, one parameter out of three was significantly improved in the LMWCP group after 12 weeks, while, compared with the placebo group, two parameters out of three in the LMWCP group were higher with significance after 12 weeks.



    Clinical Studies: Collagen for Bone Health

    No. References Findings
    1. König et al., 2018
    • The goal of the study was to investigate the effect of 12-month daily oral administration of 5 g Specific Collagen Peptides (SCP) vs control group on Bone Mineral Density (BMD) in postmenopausal women with primary, age-related reduction in BMD.
    • The primary endpoint was the change in BMD of the femoral neck and the spine after 12 months.
    • Plasma levels of bone markers—amino-terminal propeptide of type I collagen (P1NP) and C-telopeptide of type I collagen (CTX 1) were also analysed.
    • A total of 102 women completed the study who were included in the intention-to-treat (ITT) analysis (age 64.3 ± 7.2 years; Body Mass Index, BMI 23.6 ± 3.6 kg/m2.
    • The research outcomes demonstrate that the intake of specific collagen peptides increased bone mineral density in postmenopausal women with primary, age-related reduction of BMD.
    • SCP supplementation was associated with a favorable shift in bone markers, indicating increased bone formation and reduced bone degradation.
    2. Elam et al., 2015
    • This study reports the long-term efficacy of calcium-collagen chelate (CC) in reducing bone loss in postmenopausal women with osteopenia.
    • 39 women were randomly assigned to one of 2 groups: 5 g of CC containing 500 mg of elemental calcium and 200 IU vitamin D (1,25-dihydroxyvitamin D3) or control (500 mg of calcium and 200 IU vitamin D) daily for 12 months.
    • Intent-to-treat (ITT) analysis was performed using repeated measures analysis of variance pairwise comparisons and multivariate analysis to assess time and group interactions.
    • The loss of whole body bone mineral density in women taking CC was substantially lower than that of the control group at 12 months in those who completed the study and the ITT analysis.
    • The CC group had significantly reduced levels of sclerostin (main function of sclerostin is to stop (inhibit) bone formation).
    • These results supported the use of CC in reducing bone loss in osteopenic postmenopausal women.




    • Asserin, J., Lati, E., Shioya, T., & Prawitt, J. (2015). The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from anex vivomodel and randomized, placebo-controlled clinical trials. Journal Of Cosmetic Dermatology14(4), 291-301.
    • Elam, M., Johnson, S., Hooshmand, S., Feresin, R., Payton, M., Gu, J., & Arjmandi, B. (2015). A Calcium-Collagen Chelate Dietary Supplement Attenuates Bone Loss in Postmenopausal Women with Osteopenia: A Randomized Controlled Trial. Journal Of Medicinal Food18(3), 324-331.
    • Hakuta, A., Yamaguchi, Y., Okawa, T., Yamamoto, S., Sakai, Y., & Aihara, M. (2017). Anti-inflammatory effect of collagen tripeptide in atopic dermatitis. Journal Of Dermatological Science, 88(3), 357-364.
    • Kim, D., Chung, H., Choi, J., Sakai, Y., & Lee, B. (2018). Oral Intake of Low-Molecular-Weight Collagen Peptide Improves Hydration, Elasticity, and Wrinkling in Human Skin: A Randomized, Double-Blind, Placebo-Controlled Study. Nutrients10(7), 826.
    • König, D., Oesser, S., Scharla, S., Zdzieblik, D., & Gollhofer, A. (2018). Specific Collagen Peptides Improve Bone Mineral Density and Bone Markers in Postmenopausal Women—A Randomized Controlled Study. Nutrients10(1), 97.
    • Proksch, E., Segger, D., Degwert, J., Schunck, M., Zague, V., & Oesser, S. (2014a). Oral Supplementation of Specific Collagen Peptides Has Beneficial Effects on Human Skin Physiology: A Double-Blind, Placebo-Controlled Study. Skin Pharmacology And Physiology27(1), 47-55.
    • Proksch, E., Schunck, M., Zague, V., Segger, D., Degwert, J., & Oesser, S. (2014b). Oral Intake of Specific Bioactive Collagen Peptides Reduces Skin Wrinkles and Increases Dermal Matrix Synthesis. Skin Pharmacology And Physiology27(3), 113-119. doi: 10.1159/000355523

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